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Peer-reviewed articles

Scientific articles

At Royal Canin, we provide access to a selection of scientific articles  covering the latest advancements and clinical research in the field. Every study in our library is chosen to ensure that you have the most reliable, evidence-based data to support your decision-making and professional growth

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Scientific articles

Aging

Aging in cats: owner observations and clinical finding in 206 mature cats

Aging in cats owner observations and clinical finding in 206 mature cats at enrolment to the cat prospective aging and welfare study.

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Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats

Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats

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Fibroblast growth factor 23 (FGF-23) concentrations in cats

Fibroblast growth factor 23 FGF 23 concentrations in cats with early nonazotemic chronic kidney disease CKD and in healthy geriatric cats

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Validity and responsiveness of the generic health-related quality of life Instrument (VetMetrica™) in cats with dsteoarthritis

Validity and responsiveness of the generic health-related quality of life Instrument (VetMetrica™) in cats with dsteoarthritis

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Ultrasonographic monitoring of feline epaxial muscle height

Ultrasonographic monitoring of feline epaxial muscle height as part of an annual wellness examination to assess for the development of sarcopenia

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The effect of moderate dietary protein and phosphate restriction

The effect of moderate dietary protein and phosphate restriction on calcium phosphate homeostasis in healthy older cats

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Life expectancy tables for dogs and cats derived from clinical data

Life expectancy tables for dogs and cats derived from clinical data

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A new generic feline quality of life (FelQoL) questionnaire

A new generic feline quality of life (FelQoL) questionnaire: part 1 - development and validation

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A new generic feline quality of life (FelQoL) questionnaire: part 2 - initial evaluation of clinical utility

A new generic feline quality of life (FelQoL) questionnaire: part 2 - initial evaluation of clinical utility

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Behavior

Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs

Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs

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Therapeutic effects of an alpha-casozepine and L-tryptophan

Therapeutic effects of an alpha casozepine and L tryptophan supplemented diet on fear and anxiety in the cat

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Seasonal effects on locomotor and feeding rhythms in indoor cats.

Seasonal effects on locomotor and feeding rhythms in indoor cats.

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Behavioural and cognitive changes in aged pet dogs - no effects of an enriched diet and lifelong training

Behavioural and cognitive changes in aged pet dogs - no effects of an enriched diet and lifelong training

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Aging of attentiveness in border collies and other pet dog breeds

Aging of attentiveness in border collies and other pet dog breeds

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Plasma and whole blood taurine concentrations in dogs

Plasma and whole blood taurine concentrations in dogs

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Daily rhythms in food intake and locomotor activity in a colony of domestic cats

Daily rhythms in food intake and locomotor activity in a colony of domestic cats

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Accuracy assessment of spatial organization and activity of indoor cats

Accuracy assessment of spatial organization and activity of indoor cats

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Birth & growth

Birth weight in the feline species: description and factors

Birth weight in the feline species description and factors

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Growth charts for small sample sizes using unsupervised clustering

Growth charts for small sample sizes using unsupervised clustering

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 Birth weight as a risk factor for neonatal mortality breed specific approach to identify at risk puppies

Birth weight as a risk factor for neonatal mortality - breed specific approach

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Natural and artificial hyperimmune solutions impact on health in puppies

Natural and artificial hyperimmune solutions impact on health in puppies

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Epidemiological analysis of reproductive performance and kitten mortality rates in 5303 purebred queens of 45 different breeds and 28065 kittens in France

Epidemiological analysis of reproductive performance and kitten mortality rates in 5303 purebred queens and 28065 kittens in France

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Cardiology

Diet induced reduction of left ventricular wall thickness troponin I and IGF 1 in cats with asymptomatic hypertrophic cardiomyopathy

Diet induced reduction of left ventricular wall thickness troponin I and IGF 1 in cats with asymptomatic hypertrophic cardiomyopathy

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Associations between echocardiography, cardiac biomarkers, insulin metabolism, morphology and inflammation in feline asymptomatic hypertrophic cardiomyopathy

Associations between echocardiography, cardiac biomarkers, insulin metabolism, morphology and inflammation in feline asymptomatic hypertrophic cardiomyopathy

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Relationship between body size growth and echocardiographic measurements during the first two years of life in cats

Relationship between body size growth and echocardiographic measurements during the first two years of life in cats

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Dermatology

The usefulness of short course prednisolone

The usefulness of short course prednisolone during the initial phase of an elimination diet trial in dogs with food-induced atopic dermatitis

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The usefulness of short course prednisolone

Critically appraised topic on adverse food reactions of companion animals (5): discrepancies between ingredients and labeling in commercial pet foods

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Critically Appraised Topic on Adverse Food Reactions of Companion Animals

Critically appraised topic on adverse food reactions of companion animals (8): storage mites in commercial pet foods

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Critically Appraised Topic on Adverse Food Reactions of Companion Animals

Critically appraised topic on adverse food reactions of companion animals (9): time to flare of cutaneous signs after a dietary challenge in dogs and cats with food

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A novel therapeutic diet can significantly reduce the medication score

A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine month controlled study.

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Development and validation of a new standardised data collection tool

Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies.

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Veterinary dermatology logo

Evaluation of storage mite contamination of commercial dry dog food

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Evidence for an interaction between linoleic acid intake

Evidence for an interaction between linoleic acid intake and skin barrier properties in healthy dogs - a pilot study

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Testing for food specific antibodies in saliva and blood of food allergic and healthy dogs

Testing for food specific antibodies in saliva and blood of food allergic and healthy dogs

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Impacts to canine dermal microbiota associated with repeated bathing

Impacts to canine dermal microbiota associated with repeated bathing

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A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in shiba inu dogs

A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs

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Assessing d squame as a minimally invasive technique to evaluate the cutaneous immune response mrna

Assessing d squame as a minimally invasive technique to evaluate the cutaneous immune response mrna

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Gastroenterology

Validation of method for faecal sampling in cats and dogs for faecal microbiome analysis

Validation of method for faecal sampling in cats and dogs for faecal microbiome analysis

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An extensively hydrolysed protein based extruded diet

An extensively hydrolysed protein based extruded diet

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Psyllium husk powder increases defecation frequency and faecal score, bulk and moisture in healthy cats

Psyllium husk powder increases defecation frequency and faecal score

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Randomized controlled trial demonstrates nutritional management is superior to metronidazole

Randomized controlled trial demonstrates nutritional management is superior to metronidazole

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2022 ISFM consensus guidelines on management of the inappetent hospitalised cat

2022 ISFM consensus guidelines on management of the inappetent hospitalised cat

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Diet induced remission in chronic enteropathy

Diet induced remission in chronic enteropathy

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Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs

Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs

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Assessing d squame as a minimally invasive technique to evaluate the cutaneous immune response mrna

Assessing d squame as a minimally invasive technique to evaluate the cutaneous immune response mrna

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Incidence rate of otitis externa episodes in atopic dogs

Incidence rate of otitis externa episodes in atopic dogs

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A randomised controlled study demonstrates that diet can contribute to the clinical management

A randomised controlled study demonstrates that diet can contribute to the clinical management

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Machine learning model for an app-based tool

Machine learning model for an app-based tool

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Glycyrrhizin intake higher than the current guidelines has no detectable hypermineralocorticoid like effect in dogs

Glycyrrhizin intake higher than the current guidelines has no detectable hypermineralocorticoid like effect in dogs

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The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs

The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs

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Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs

Association of the canine ATP7A and ATP7B with hepatic copper accumulation in dobermann dogs

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Nutrition

Measurement of postprandial incremental glucose and insulin changes in healthy dogs

Measurement of postprandial incremental glucose and insulin changes in healthy dogs: influence of food adaptation and length of time of blood sampling

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Glycemic and Insulinemic responses in dogs

Glycemic and insulinemic responses after Ingestion of commercial foods in healthy dogs

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Linoleate enriched diet

Linoleate enriched diet increases both linoleic acid esterified to omega hydroxy

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Long term follow up after weight management in obese dogs: the role of the diet in preventing regain

Long term follow up after weight management in obese dogs: the role of the diet in preventing regain

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A dietary supplement containing nucleotides oligosaccharides vitamin E

A dietary supplement containing nucleotides oligosaccharides vitamin E

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The oral 13C bicarbonate technique for determination of energy expenditure in dogs

The oral 13C bicarbonate technique for determination of energy expenditure in dogs

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Estimation of energy expenditure using the oral 13C-bicarbonate

Estimation of energy expenditure using the oral 13C bicarbonate

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Quantification of vitamin D3 in commercial dog food and comparison with AAFCO recommendations and manufacturers concentrations

Quantification of vitamin D3 in commercial dog food and comparison with AAFCO recommendations and manufacturers concentrations

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Overweight & obesity

Evolution of blood parameters during weight loss in experimental obese Beagle dogs

Evolution of blood parameters during weight loss in experimental obese Beagle dogs

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Effect of dietary fat and energy on body weight and composition after gonadectomy in cats

Effect of dietary fat and energy on body weight and composition after gonadectomy in cats

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Dietary energy restriction and successful weight loss in obese client owned dogs

Dietary energy restriction and successful weight loss in obese client owned dogs

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A high protein high fiber diet designed for weight loss improves satiety in dogs

A high protein high fiber diet designed for weight loss improves satiety in dogs

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Change in body condition during weight loss in obese client owned cats

Change in body condition during weight loss in obese client owned cats loss of lean tissue correlates with overall percentage of weight lost

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Novel dietary strategies can improve the outcome of weight loss programmes in obese client-owned cats

Novel dietary strategies can improve the outcome of weight loss programmes in obese client-owned cats

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Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs

Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs

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A high protein high fibre diet improves weight loss in obese dogs

A high protein high fibre diet improves weight loss in obese dogs

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Age and body weight effects on glucose and insulin tolerance

Age and body weight effects on glucose and insulin tolerance in colony cats maintained since weaning on high dietary carbohydrate

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Imprecision when using measuring cups to weigh out extruded dry kibbled food

Imprecision when using measuring cups to weigh out extruded dry kibbled food

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Long term follow up after weight management in obese cats

Long term follow up after weight management in obese cats

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Incorporation of exercise using an underwater treadmill

Incorporation of exercise using an underwater treadmill and active client education into a weight management program for obese dogs

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Low-maintenance energy requirements of obese dogs after weight loss

Low maintenance energy requirements of obese dogs after weight loss

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Do feeding practices of obese dogs before weight loss affect the success of weight management

Do feeding practices of obese dogs before weight loss affect the success of weight management

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Quality of life is reduced in obese dogs but improves after successful weight loss

Quality of life is reduced in obese dogs but improves after successful weight loss

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Theoretical evaluation of risk for nutritional deficiency with caloric restriction in dogs

Theoretical evaluation of risk for nutritional deficiency with caloric restriction in dogs

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Effects of weight loss in obese cats

Effects of weight loss in obese cats on biochemical analytes related to inflammation and glucose homeostasis

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Obesity-related metabolic dysfunction in dogs

Obesity related metabolic dysfunction in dogs a comparison with human metabolic syndrome

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Proliferation capacity of T-lymphocytes

Proliferation capacity of T-lymphocytes is affected transiently after a long-term weight gain in Beagle dogs

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Faster growth rate in ad libitum cats

Faster growth rate in ad libitum cats a risk factor predicting the likelihood of becoming overweight during adulthood.

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Oxygenation and ventilation characteristics in obese sedated dogs before and after weight loss: a clinical trial.

Oxygenation and ventilation characteristics in obese sedated dogs before and after weight loss: a clinical trial.

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Seasonal variation in the voluntary food intake of domesticated cats

Seasonal variation in the voluntary food intake of domesticated cats Felis Catus

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A moderate fat, low energy dry expanded diet reduces gain

A moderate fat low energy dry expanded diet reduces gain in body condition score when fed as part of a post neutering weight-control regimen in growing pet cats

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Long term follow up after weight management in obese cats

Long term follow up after weight management in obese cats

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Owner misperception of canine body condition

Owner misperception of canine body condition persists despite use of a body condition score chart

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Feeding obese dogs during weight loss is on average cost-neutral

Feeding obese dogs during weight loss is on average cost-neutral

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Cohort study of the success of controlled weight loss programs for obese dogs

Cohort study of the success of controlled weight loss programs for obese dogs

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Can you estimate body composition in dogs from photographs

Can you estimate body composition in dogs from photographs

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Obese dogs with and without obesity related metabolic dysfunction

Obese dogs with and without obesity related metabolic dysfunction a proteomic approach

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Higher neonatal growth rate and body condition score

Higher neonatal growth rate and body condition score at 7 months are predictive factors of obesity in adult female Beagle dogs

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Success of a weight loss plan for overweight dogs

Success of a weight loss plan for overweight dogs the results of an international weight loss study

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An international multi centre cohort study of weight loss in overweight cats

An international multi centre cohort study of weight loss in overweight cats differences in outcome in different geographical locations

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Effects of high-fat diet at two energetic levels

Effects of high fat diet at two energetic levels on fecal microbiota, colonic barrier and metabolic parameters in dogs.

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Maintenance energy requirements in cats

Maintenance energy requirements in cats following controlled weight loss an observational study

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Partial weight reduction protocols in cats

Partial weight reduction protocols in cats lead to better weight outcomes compared with complete protocols in cats with obesity

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Weight loss outcomes are generally worse for dogs and cats with class II obesity, defined as > 40% overweight

Weight loss outcomes are generally worse for dogs and cats with class II obesity, defined as > 40% overweight

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The effect of obesity and subsequent weight reduction

The effect of obesity and subsequent weight reduction on cardiac structure and function in dogs

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The effect of obesity and subsequent weight reduction on cardiac morphology and function in cats

The effect of obesity and subsequent weight reduction on cardiac morphology and function in cats

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Overweight and obese body condition in ∼4.9 million dogs and ∼1.3 million cats

Overweight and obese body condition in 4 9 million dogs and 1 3 million cats seen at primary practices across the USA

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Comparison of voluntary food intake and palatability of commercial weight loss diets in healthy dogs and cats

Comparison of voluntary food intake and palatability of commercial weight loss diets in healthy dogs and cats

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Variables causally associated with hair cortisol concentration in dogs with obesity a Bayesian analysis

Variables causally associated with hair cortisol concentration in dogs with obesity a Bayesian analysis

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The oral 13C bicarbonate technique for determination of energy expenditure in dogs

The oral 13C bicarbonate technique for determination of energy expenditure in dogs

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Untargeted fecal metabolome analysis in obese dogs after weight loss

Untargeted fecal metabolome analysis in obese dogs after weight loss

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Use of reduced energy content maintenance diets for modest weight reduction in overweight cats and dogs

Use of reduced energy content maintenance diets for modest weight reduction in overweight cats and dogs

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Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation

Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation

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Comparison of the effects of different kibble shape on voluntary food intake

Comparison of the effects of different kibble shape on voluntary food intake and palatability of weight loss diets in pet dogs

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Effects of a high protein increased fibre dry diet supplemented with omega 3 fatty acids

Effects of a high protein increased fibre dry diet supplemented with omega 3 fatty acids

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Effects and synergy of feed ingredients on canine neoplastic cell proliferation

Effects and synergy of feed ingredients on canine neoplastic cell proliferation

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Pediatrics

Comparison of growth in neutered domestic shorthair kittens

Comparison of growth in neutered domestic shorthair kittens

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A placebo controlled study of the effects of Saccharomyces cerevisiae

A placebo controlled study of the effects of Saccharomyces cerevisiae

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Dietary supplementation with nucleotides by MDPI

Dietary supplementation with nucleotides

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PLOS One

Growth standard charts for monitoring bodyweight in intact domestic shorthair kittens from the USA

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Dietary supplementation of nucleotides and oligosaccharides in kittens reduces the expression of circulating miR-1-3p, miR-133a-3p, miR-206-3p and miR-383-5p Frontiers

Dietary supplementation of nucleotides and oligosaccharides in kittens

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Preventative veterinary medicine

Validation of a fecal scoring scale in puppies during the weaning period

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Environmental risk factors in puppies and kittens

Environmental risk factors in puppies and kittens

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Nurturing futures: the role of veterinary nurses in promoting the healthy development of puppies and kittens

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Renal disease

The role of phosphorus in the pathophysiology of chronic kidney disease

The role of phosphorus in the pathophysiology of chronic kidney disease

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Risk factors for development of chronic kidney disease in cats

Risk factors for development of chronic kidney disease in cats

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Chronic kidney disease in cats and the risk of total hypercalcemia

Chronic kidney disease in cats and the risk of total hypercalcemia

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Prognostic importance of plasma total magnesium in a cohort of cats

Prognostic importance of plasma total magnesium in a cohort of cats with azotemic chronic kidney disease

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An artificial neural network based model to predict chronic kidney disease in aged cats

An artificial neural network based model to predict chronic kidney disease in aged cats

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Risk factors associated with disturbances of calcium homeostasis

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate restricted diet in cats with chronic kidney disease

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Clinical progression of cats with early-stage chronic kidney disease

Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios.

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Risk factors and implications associated with renal mineralization

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats

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Dietary magnesium supplementation in cats with chronic kidney disease

Dietary magnesium supplementation in cats with chronic kidney disease a prospective double-blind randomized controlled trial.

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Survival of cats with naturally occurring chronic renal failure

Survival of cats with naturally occurring chronic renal failure effect of dietary management

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The effect of attenuating dietary phosphate restriction on blood

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia

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Fibroblast growth factor 23 in feline chronic kidney disease

Fibroblast growth factor 23 in feline chronic kidney disease

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Detection of nephrocalcinosis using ultrasonography

Detection of nephrocalcinosis using ultrasonography

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Ionized hypercalcemia in cats with azotemic chronic kidney disease

Ionized hypercalcemia in cats with azotemic chronic kidney disease

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Observations on the prognostic importance of plasma total magnesium in a cohort of cats with kidney disease

Observations on the prognostic importance of plasma total magnesium in a cohort of cats with kidney disease

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Calcitonin response to naturally occurring ionized hypercalcemia in cats with chronic kidney disease

Calcitonin response to naturally occurring ionized hypercalcemia in cats with chronic kidney disease

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Reproduction

Monitoring of the newborn dog and prediction of neonatal mortality

Monitoring of the newborn dog and prediction of neonatal mortality

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Start of life

A dietary supplement containing nucleotides oligosaccharides vitamin E

A dietary supplement containing nucleotides oligosaccharides vitamin E

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Impact of compensatory growth on survival in newborn kittens

Impact of compensatory growth on survival in newborn kittens

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Prioritization of appearance over health and temperament

Prioritization of appearance over health and temperament

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Characterization of the semen microbiota of healthy stud dogs

Characterization of the semen microbiota of healthy stud dogs

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Uterine issues in infertile queens nine cases

Uterine issues in infertile queens nine cases

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Urinary system

Long-term safety of dietary salt

Long-term safety of dietary salt: A 5-year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats (PEANUT study)

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Increasing dietary sodium chloride promotes urine dilution

Increasing dietary sodium chloride promotes urine dilution and decreases struvite and calcium oxalate relative supersaturation in healthy dogs and cats

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Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets

Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets

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Analysis of 7866 canine and feline uroliths submitted between 2014 and 2020 in the Netherlands

Analysis of 7866 canine and feline uroliths submitted between 2014 and 2020 in the Netherlands

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The effect of urine acidification on calcium oxalate relative supersaturation in cats

The effect of urine acidification on calcium oxalate relative supersaturation in cats

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On this page you will find the following:

Aging

Behavior

Birth & growth

Cardiology

Dermatology

Gastroenterology

Nutrition

Other

Overweight / obesity

Pediatrics

Renal disease

Reproduction

Start of life

Urinary system